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ea0037gp.04.01 | Steroids | ECE2015

Dual 5α-reductase inhibition causes hepatic lipid accumulation in man

Hazlehurst Jonathan , Oprescu Andrei , Nikolaou Nikolaos , Grinbergs Annabel , Davies Nigel , Flintham Robert , Hughes Beverley , Taylor Angela , Yu Jinglei , Wagenmakers Anton , Tomlinson Jeremy

5α reductases 1 and 2 (SRD5A1 and SRD5A2) metabolise cortisol into inactive 5α-dihydrocortisol contributing to the regulation of cortisol availability in addition to their established role in the generation of dihydrotestosterone from testosterone. Dutasteride and finasteride are commonly prescribed to patients with benign prostatic hyperplasia but their potential metabolic effects have only recently been identified. Dutasteride inhibits both SRD5A1and SRD5A2 whilst ...

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ePoster

ea0038oc2.1 | Translational pathophysiology and therapeutics | SFEBES2015

Dual 5-α reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver

Hazlehurst Jonathan , Oprescu Andrei , Nikolaou Nikolaos , Guida Riccardo Di , Grinbergs Annabel , Davies Nigel , Flintham Robert , Armstrong Matthew , Taylor Angela , Hughes Beverly , Yu Jinglei , Hodson Leanne , Dunn Warwick , Tomlinson Jeremy

Background and aims: 5α reductase 1 and 2 (SRD5A1 (expressed in liver and adipose), SRD5A2 (expressed in liver) inactivate cortisol to 5α-dihydrocortisol in addition to their role in the generation of dihydrotestosterone and therefore regulate the tissue availability of cortisol. Dutasteride (dual SRD5A1 and SRD5A2 inhibitor) and Finasteride (selective SRD5A2 inhibitor) are commonly prescribed, but their potential metabolic effects have only recently been identified....

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Endocrine Abstracts

Dual 5α-reductase inhibition causes hepatic lipid accumulation in man

Dual 5-α reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver

BiosciAbstracts